I don't think the levels are that comparable, for 16 you'd need a lot of boosts unless some new tech is found. For such a short level, going for more boosts is sheer madness, given that 17 potential requires a lot of luck already, as well as a good warp. 52 is almost all execution, it's super tight and requires a fairly rare combo of boosts. And a boostless, 1.2 53 also demonstrated the possibility.
I'd estimate 17s have at least 6 or 7 boosts, correct me if I'm wrong. It's also possible to get away with a minor mistake or two which is why so many people have it. The fewest I've seen is 5, but I haven't seen every video or seen any dupes from better players.
9 boosts with near perfect movement would be enough to get 16, I'd think, and it might even be possible with fewer, but a run like that might not even be possible. I'd be interested to know more about Bond's hitstun and enemy "slotting" mechanics, particularly on Agent, since I'm not sure the game's RNG (I'm guessing it's pseudo-random like most games) could produce such a godly sequence of boosts in such a short time.
It would look something like this: 1 into the hallway, 2 in the hallway, 1 down the stairs, 1 around the table, and 3-4 unpausing and on the way out. The one down the stairs is fairly rare, and not that helpful since it can throw off your line. I suppose the klobb guard after you take the photo might be able to hit you potentially, though I don't remember getting that boost myself, and this is assuming all the other guards miss. And not every boost would save .3; the level is tight and the glass door acts as a bottleneck if you did manage to have a 6 boost start or so. Plus the black guards are way more likely to hit you, which can also ruin your warp or otherwise troll you by eating your inputs.
What's the fewest boosts on a completed 17? And who has the most boosts? I know a 12 quitout is possible, and 4-5 boost endings aren't unheard of. If the top 10 players did put in hundreds of hours, there's a slight chance one of them could get it, but there really isn't an example of a true 16 pace run yet.
I'd say B1 would need a new .1 or .2 time save, then I think top players might go for it.